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A green and clean pathway: one pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-c]pyrazoles under catalyst-free and solvent-free conditions

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Abstract

A mild, eco-efficient and metal-free synthetic protocol for the production of biologically significant scaffold dihydropyrano[2,3-c]pyrazoles via reaction between ethylacetoacetate (1), hydrazine hydrate (2), aromatic aldehydes (3) and malononitrile (4) as reactants and exploiting visible light as a reaction promoter has been developed. Cost effectiveness, nontoxicity, being catalyst-free and solvent-free, the easy-availability of reactants and non-involvement of specific glasswares and a photo-reactor system are some of the significant traits of the present protocol. The scope of the current methodology is further extended by using diethyl acetylene dicarboxylate (6) as a reactant in place of ethylacetoacetate.

Graphical abstract: A green and clean pathway: one pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-c]pyrazoles under catalyst-free and solvent-free conditions

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Publication details

The article was received on 16 May 2017, accepted on 22 Aug 2017 and first published on 23 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01688C
Citation: New J. Chem., 2017, Advance Article
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    A green and clean pathway: one pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-c]pyrazoles under catalyst-free and solvent-free conditions

    B. Pati Tripathi, A. Mishra, P. Rai, Y. Kumar Pandey, M. Srivastava, S. Yadav, J. Singh and J. Singh, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01688C

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