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Issue 15, 2017
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Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes

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Abstract

Under identical synthetic conditions, the reaction of aqua-nitro complexes of ruthenium nitrosyl with methyl-substituted pyridines results in drastically different products. While 3- and 4-MePy react similarly to pyridine giving monomeric complexes [RuNO(NO2)2L2OH] with good yields (70–80%), the sterically hindered 2-MePy forms a dimeric complex [(RuNO(2-MePy)(NO2)(μ-NO2))2μ-O] with only one N-heterocycle coordinated to the ruthenium center. Further investigation of photoinduced (445 nm) isomerization of Ru–NO (GS) to Ru–ON (MS1) at 80 K also shows different behaviors. Complexes with 3- and 4-MePy form metastable states with populations equal to 25% and 40% according to IR spectroscopy data. Activation parameters for the reverse decay reaction (MS1 → GS) determined from DSC are lg k0 = 12.0(0.2), Ea = 56.0(0.7) kJ mole−1 and lg k0 = 13.7(0.1), Ea = 61.8(0.4) kJ mole−1 for the 3-MePy and 4-MePy complex. A dimeric complex with 2-MePy does not undergo any changes after irradiation. Estimates of cytotoxicity in human mammary adenocarcinoma (MCF-7) and immortalized human embryonic kidney (HEK-293) cell lines demonstrate that complexes with 3-MePy and 4-MePy exhibited a 50% decrease in the growth of cancer cells at remarkably low and comparable concentrations (0.82–3.2 μM).

Graphical abstract: Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes

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Publication details

The article was received on 10 May 2017, accepted on 21 Jun 2017 and first published on 22 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01602F
Citation: New J. Chem., 2017,41, 7758-7765
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    Influence of pyridine-like ligands on the structure, photochemical and biological properties of nitro-nitrosyl ruthenium complexes

    G. A. Kostin, A. A. Mikhailov, N. V. Kuratieva, D. P. Pischur, D. O. Zharkov and I. R. Grin, New J. Chem., 2017, 41, 7758
    DOI: 10.1039/C7NJ01602F

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