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Structurally different mono, bi and trinuclear Pd(II) complexes and their DNA/Protein interaction, DNA cleavage, anti-oxidant, anti-microbial and cytotoxicity studies

Abstract

A series of new structurally different Pd(II) complexes were obtained from the reactions between K2[PdCl4], 3-methoxysalicylaldehyde-4(N)-substituted thiosemicarbazone [H2L1-H2L4] and bis(diphenylphosphino)ethane [dppe]. All the complexes were characterized by various spectral techniques (IR, electronic, 1H-NMR and mass spectroscopy). The crystal structures of the complexes 1, 3, 4 and 3a & 4a have been determined by X-ray crystallographic technique. The interaction of new complexes with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) have been evaluated by various spectroscopic methods, which showed the interaction potential of the complexes with CT-DNA and BSA. Further, they cleaved supercoiled DNA pBR322. Anti-oxidant profile of the complexes found better than the standards against 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH) and superoxide anion radicals. Antibacterial activity of the complexes against five pathogenic bacteria such as Staphylococcus aureus, Salmonella typhi, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa found better than their parent ligands. The complexes exhibited potential cytotoxicity against human breast cancer cells (MCF-7) in the following order 4>3>1>cisplatin>2.

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Publication details

The article was received on 08 May 2017, accepted on 02 Aug 2017 and first published on 02 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01556A
Citation: New J. Chem., 2017, Accepted Manuscript
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    Structurally different mono, bi and trinuclear Pd(II) complexes and their DNA/Protein interaction, DNA cleavage, anti-oxidant, anti-microbial and cytotoxicity studies

    S. Arumugam, R. Jain, S. Devaraj, K. Giriraj, F. Dallemer and R. Prabhakaran, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ01556A

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