Issue 15, 2017

Highly water soluble room temperature superionic liquids of APIs

Abstract

Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

Graphical abstract: Highly water soluble room temperature superionic liquids of APIs

Supplementary files

Article information

Article type
Letter
Submitted
26 Apr 2017
Accepted
06 Jun 2017
First published
06 Jun 2017

New J. Chem., 2017,41, 6986-6990

Highly water soluble room temperature superionic liquids of APIs

G. V. S. M. Carrera, M. M. Santos, A. Costa, L. P. N. Rebelo, I. M. Marrucho, M. Nunes da Ponte and L. C. Branco, New J. Chem., 2017, 41, 6986 DOI: 10.1039/C7NJ01398A

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