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Highly water soluble room temperature superionic liquids of APIs

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Abstract

Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

Graphical abstract: Highly water soluble room temperature superionic liquids of APIs

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Publication details

The article was received on 26 Apr 2017, accepted on 06 Jun 2017 and first published on 06 Jun 2017


Article type: Letter
DOI: 10.1039/C7NJ01398A
Citation: New J. Chem., 2017, Advance Article
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    Highly water soluble room temperature superionic liquids of APIs

    G. V. S. M. Carrera, M. M. Santos, A. Costa, L. P. N. Rebelo, I. M. Marrucho, M. Nunes da Ponte and L. C. Branco, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01398A

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