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Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in aqueous medium and mitochondria of living cells

Abstract

Mitochondrion is one of the major targets for localization of mercury ions, where serious mercury-induced toxicity has been well documented. Here, we design two fluorinated heptamethine cyanine dyes coupled with thymines on the N-alkyl chains, which can specifically chelate with Hg2+ by forming T-Hg-T complex to sensitively detect Hg2+ in both aqueous solution and the mitochondria of living cells. Further studies revealed that the introduction of fluorine atoms on thymines would significantly enhances the binding ability of T-Hg-T, providing clues to develop more specific and sensitive Hg2+ sensors.

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Publication details

The article was received on 21 Apr 2017, accepted on 10 Jul 2017 and first published on 11 Jul 2017


Article type: Paper
DOI: 10.1039/C7NJ01327B
Citation: New J. Chem., 2017, Accepted Manuscript
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    Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in aqueous medium and mitochondria of living cells

    L. lei, X. Tan, S. Luo and C. Shi, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ01327B

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