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Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones

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Abstract

Herein, a novel and efficient intermolecular cyclization of 2-aminoacetophenones with aldehydes was developed for the synthesis of 2-aryl-4-quinolones through C–C and C–N bond formation. Mild conditions, good functional group tolerance, and substrates without prefunctionalization make this protocol practical, and this strategy will stimulate keen interest in fields of chemistry and biology.

Graphical abstract: Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones

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Publication details

The article was received on 18 Apr 2017, accepted on 30 May 2017 and first published on 30 May 2017


Article type: Letter
DOI: 10.1039/C7NJ01293D
Citation: New J. Chem., 2017, Advance Article
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    Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones

    H. Ma, C. Guo, Z. Zhan, G. Lu, Y. Zhang, X. Luo, X. Cui and G. Huang, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01293D

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