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DOX-UCNPs@mSiO2-TiO2 nanocomposites for near-infrared photocontrolled chemo/photodynamic therapy

Abstract

Currently, the incorporating multiple therapeutic functions into one nanostructure has attracted more and more attention for the development of efficient anticancer agents. In this work, uniform core-shell UCNPs@mSiO2 nanocomposite was prepared as the carrier to construct the NIR controlled chemotherapy associated with photodynamic therapy (PDT). In view of the novel UV emission, the semiconductor photosensitiver TiO2 was exploited due to the high efficiency and chemical stability. The host-modification method was used to integrate TiO2 doping and mesoporous structure, which can store anticancer drug molecules (doxorubicin, DOX). To improve the utilization of emission, a photolabile o-nitrobenzyl derivative was incorporated to form sensitive linker (NB linker) as “gate” to make sure the few prematurity. Under NIR irradiation, the UV emission can not only excite TiO2 to produce reactive oxygen species (ROS), but also induce the break of NB linker as well as drug release. The NIR triggered performances were further demonstrated by the cell experiment using HeLa cell as the model cancer cell. The synergistic effect of chemotherapy and PDT induce the enhanced cytotoxicity which is more powerful than their simple effects added together. Therefore, the novel NIR light-controlled double-therapeutic nanocomposite should be a potential candidate in anticancer agent.

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Supplementary files

Publication details

The article was received on 18 Apr 2017, accepted on 09 Jun 2017 and first published on 09 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01291H
Citation: New J. Chem., 2017, Accepted Manuscript
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    DOX-UCNPs@mSiO2-TiO2 nanocomposites for near-infrared photocontrolled chemo/photodynamic therapy

    Y. H. Chen, R. Tong, N. An, H. Lin and F. Qu, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ01291H

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