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Issue 14, 2017
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Central composite design in HPMC granulation and correlations between product properties and process parameters

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Abstract

Particulate solids have received great interest in many industrial fields for both marketing reasons and technological aspects. In this study granular systems were achieved by using a wet granulation process using hydroxypropyl methylcellulose (HPMC) and distilled water as the binder phase. Particulates with a defined size (450–2000 μm) and good flowability together with a high granulation process yield, to reduce manufacturing scrap, were produced. To this aim a bench scale low-shear rate granulator apparatus was used; three process parameters were varied (impeller rotation speed, binder volume at constant mass, and binder flow rate) and, for each parameter, three intensities have been used. HPMC granule production was planned using the Central Composite Design (CCD) statistical protocol, which allowed us to minimize the number of runs to be performed for obtaining information about the relationship between granule properties and process parameters. The produced granules were stabilized by using a dedicated dynamic drying apparatus, then separated by sieving and then characterized in terms of size and flowability properties. The results of the experimental campaign have been used to develop semi-empirical correlations between granulated product properties and process parameters. A second-order polynomial law has shown the best comparison between experimental data and model predicted values. These correlations can constitute a reliable tool to help us to know more on the effect of operative parameter changes in HMPC or similar particulate solid production.

Graphical abstract: Central composite design in HPMC granulation and correlations between product properties and process parameters

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Publication details

The article was received on 17 Apr 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01280B
Citation: New J. Chem., 2017,41, 6504-6513
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    Central composite design in HPMC granulation and correlations between product properties and process parameters

    V. De Simone, A. Dalmoro, G. Lamberti, M. d'Amore and A. A. Barba, New J. Chem., 2017, 41, 6504
    DOI: 10.1039/C7NJ01280B

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