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Mechanical and biological investigations of chitosan-polyvinyl alcohol based ZrO2 doped porous hybrid composites for bone tissue engineering applications

Abstract

Here, ZrO2 nanoparticles (NPs) doped CTS-PVA-HAP composites (ZrCPH I-III) have been developed and characterized by FT-IR and XRD studies to mimic the human bone for bone tissue engineering applications. Interconnected porous structures of these composites have been observed via SEM and porosities are in the range of human cancellous bone. These composites also have good swelling ability both in aqueous and SBF medium. Addition of ZrO2 NPs into CTS-PVA-HAP composites has improved the tensile strengths of ZrCPH I-III compared to previously reported CTS-PVA-HAP composites and maximum tensile strength has been obtained with ZrCPH III (CTS:PVA:HAP-ZrO¬2 = 55:30:15 wt %), having highest ZrO2 content (0.3 wt %). Strongest antimicrobial effect has also been observed for ZrCPH III having maximum amount of nano-HAP-ZrO2. Cytocompatibility with human osteoblastic MG-63 cells are also established and highest cell proliferation has been observed with ZrCPH III. Thus, ZrCPH III should have the potential to be applied as bone tissue engineering material.

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Publication details

The article was received on 14 Apr 2017, accepted on 13 Jun 2017 and first published on 13 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01246B
Citation: New J. Chem., 2017, Accepted Manuscript
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    Mechanical and biological investigations of chitosan-polyvinyl alcohol based ZrO2 doped porous hybrid composites for bone tissue engineering applications

    A. Bhowmick, N. Pramanik, T. Mitra, A. Gnanamani, M. Das and P. P. Kundu, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ01246B

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