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Structural analysis and magnetic induced hyperthermia of Fe3+ and Mn2+ substituted β-Ca3(PO4)2

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Abstract

The design of attractive materials for application in hyperthermia therapy has been in huge demand during recent years. To achieve this aim, magnetic features are induced in bioactive β-tricalcium phosphate [β-TCP, β-Ca3(PO4)2] through Fe3+ and Mn2+ co-substitution. A series of Fe3+/Mn2+ co-substitutions in β-Ca3(PO4)2 are synthesized through a co-precipitation route. Detailed structural analysis emphasizes the formation of β-Ca3(PO4)2 solid solutions with Fe3+/Mn2+ co-substitutions. Both Fe3+ and Mn2+ prefer to occupy the Ca2+(5) site of β-Ca3(PO4)2 up to a limit of ∼10 mol% and thereafter get accommodated at the Ca2+(4) lattice site. The synthesized materials exhibit magnetic features and heating ability tests certify their potential role in hyperthermia applications. Haemolytic and cytotoxicity tests confirm the biocompatibility of the synthesized thermoseeds.

Graphical abstract: Structural analysis and magnetic induced hyperthermia of Fe3+ and Mn2+ substituted β-Ca3(PO4)2

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Publication details

The article was received on 18 Apr 2017, accepted on 20 Sep 2017 and first published on 05 Oct 2017


Article type: Paper
DOI: 10.1039/C7NJ01228D
Citation: New J. Chem., 2017, Advance Article
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    Structural analysis and magnetic induced hyperthermia of Fe3+ and Mn2+ substituted β-Ca3(PO4)2

    R. Singh, M. Srivastava, N. K. Prasad, S. Awasthi, A. Kumar Dhayalan and S. Kannan, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01228D

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