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Perovskite LaCoO3 nanoparticles as enzyme mimetics: catalytic properties, mechanism and its application in biosensing for dopamine

Abstract

Perovskite materials LaCoO3 (LCO NPs) were prepared and found to possess both peroxidase-like and catalase-like catalytic activities. The LCO NPs can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H2O2 generating a blue color change in acid conditions or decompose the H2O2 in alkaline conditions with the generation of oxygen. Catalytic kinetics together with the possible mechanism of the peroxidase-like activity was investigated. The peroxidase-like catalytic property of LaCoO3 nanoparticles was found to originate from their ability of the acceleration of electron transfer. Then based on their peroxidase property, LCO NPs were applied to determine the dopamine by using colorimetric method with the dopamine-dependent successive inhibition reaction. The linear range of dopamine sensing was found out to be 0.5μM- 20μM and the detection limit (LOD) was also discussed. The standard addition experiments were further performed with recoveries between 95.6% and 103.6%, and all the relative standard deviations (RSDs) were below 4.0%. The determination of dopamine therefore showed high accuracy and efficiency and has potential for diagnosis of dopamine-related disease.

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Publication details

The article was received on 09 Apr 2017, accepted on 21 Jun 2017 and first published on 05 Jul 2017


Article type: Paper
DOI: 10.1039/C7NJ01177F
Citation: New J. Chem., 2017, Accepted Manuscript
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    Perovskite LaCoO3 nanoparticles as enzyme mimetics: catalytic properties, mechanism and its application in biosensing for dopamine

    K. Wang, J. Song, X. Duan, J. Mu and Y. Wang, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ01177F

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