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Issue 12, 2017
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Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazoles

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Abstract

An efficient and green approach for the sp3 C–H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Nitrostyrylisoxazoles were proven to be good C[double bond, length as m-dash]C electrophilic acceptors for the construction of various azaarene-containing Michael addition products. This method provides an efficient and environmentally benign method for the one-pot synthesis of biologically important azaarene-substituted isoxazole derivatives in good yields. The important aspects of the present methodology are the use of non-toxic solvent, that it is catalyst free, the ease of purification and the large substrate scope.

Graphical abstract: Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazoles

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Publication details

The article was received on 08 Apr 2017, accepted on 18 May 2017 and first published on 19 May 2017


Article type: Letter
DOI: 10.1039/C7NJ01165B
Citation: New J. Chem., 2017,41, 4783-4787
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    Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazoles

    D. Nagaraju, E. Rajanarendar, P. Praveen Kumar and M. Nagi Reddy, New J. Chem., 2017, 41, 4783
    DOI: 10.1039/C7NJ01165B

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