Issue 15, 2017

Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

Abstract

A series of zerumbone pendant derivatives were synthesized and evaluated for their α-glucosidase, α-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in micromolar concentration. In addition, investigations were carried out to screen the cytotoxic effects of some selected derivatives against various cancer cell lines viz., A549, HCT116, HeLa, HT1080 and MDAMB231. Two of the derivatives showed potent activity towards HCT116 and HeLa cell lines.

Graphical abstract: Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

Supplementary files

Article information

Article type
Letter
Submitted
03 Apr 2017
Accepted
25 May 2017
First published
26 May 2017

New J. Chem., 2017,41, 6960-6964

Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

B. P. Dhanya, G. Gopalan, T. R. Reshmitha, J. Saranya, P. Sharathna, I. G. Shibi, P. Nisha and K. V. Radhakrishnan, New J. Chem., 2017, 41, 6960 DOI: 10.1039/C7NJ01098B

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