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Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

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Abstract

A series of zerumbone pendant derivatives were synthesized and evaluated for their α-glucosidase, α-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in micromolar concentration. In addition, investigations were carried out to screen the cytotoxic effects of some selected derivatives against various cancer cell lines viz., A549, HCT116, HeLa, HT1080 and MDAMB231. Two of the derivatives showed potent activity towards HCT116 and HeLa cell lines.

Graphical abstract: Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

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Publication details

The article was received on 03 Apr 2017, accepted on 25 May 2017 and first published on 26 May 2017


Article type: Letter
DOI: 10.1039/C7NJ01098B
Citation: New J. Chem., 2017, Advance Article
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    Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities

    B. P. Dhanya, G. Gopalan, T. R. Reshmitha, J. Saranya, P. Sharathna, I. G. Shibi, P. Nisha and K. V. Radhakrishnan, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01098B

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