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Efficient synthetic route to aromatic secondary amines via Pd/RuPhos/TBAB-catalyzed cross coupling

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Abstract

Herein, C–N cross coupling methodology was developed for the synthesis of a diverse range of nitro-substituted secondary amines. A variety of strained, aliphatic, and aromatic precursors were effectively used, with low catalyst and ligand loading ratios resulting in product formation in good yield. This method can act as an alternative to nucleophilic addition reactions. To cross couple electron-donating, electron-withdrawing, neutral, and aliphatic primary amines with alkyl/aryl halides, a combination of RuPhos and TBAB was carefully tuned. Further, characterization of these molecules was carried out using FT-IR, 1H-NMR, 13C-NMR, 19F-NMR, single crystal XRD, and C, H, and N elemental analyses.

Graphical abstract: Efficient synthetic route to aromatic secondary amines via Pd/RuPhos/TBAB-catalyzed cross coupling

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Publication details

The article was received on 03 Apr 2017, accepted on 05 Jun 2017 and first published on 05 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01095H
Citation: New J. Chem., 2017, Advance Article
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    Efficient synthetic route to aromatic secondary amines via Pd/RuPhos/TBAB-catalyzed cross coupling

    P. Gaur, K. Durga Bhaskar Yamajala and S. Banerjee, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01095H

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