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A novel two-photon fluorescent probe for hydrogen sulfide in living cells using an acedan–NBD amine dyad based on FRET process with high selectivity and sensitivity

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Abstract

Two-photon imaging, due to its unique advantage to utilize near-infrared light as the excitation source, has emerged as an important tool for biomedical research. Herein, the first NBD amine based two-photon fluorescence probe L using a FRET strategy was developed for detecting H2S in vitro and in vivo. The probe L not only afforded high selectivity and sensitivity for the detection of H2S, but also displayed a linear response to H2S with a low detection limit of 24 nM. Furthermore, the living cell experiments indicated that L can be effective for the both exogenous and endogenous detection of H2S inside living cells by two-photon fluorescence imaging.

Graphical abstract: A novel two-photon fluorescent probe for hydrogen sulfide in living cells using an acedan–NBD amine dyad based on FRET process with high selectivity and sensitivity

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Publication details

The article was received on 31 Mar 2017, accepted on 05 Jun 2017 and first published on 05 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01080J
Citation: New J. Chem., 2017, Advance Article
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    A novel two-photon fluorescent probe for hydrogen sulfide in living cells using an acedan–NBD amine dyad based on FRET process with high selectivity and sensitivity

    Y. Tang and G. Jiang, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01080J

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