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A Fluorescent Probe for Ratiometric Imaging Exogenous and Intracellular Formed Hypochlorous Acid in Lysosomes

Abstract

We have developed a new lysosome-targeting ratiometric fluorescent probe (FL-HA) for specific determination of HOCl in living cells. The developed probe exhibits accurate lysosome-targeting ability, good signal resolution, and high selectivity. Moreover, fluorescence imaging shows that FL-HA could be used as a probe for ratiometric visualization of exogenous and endogenous HOCl in lysosomes with a high colocalization coefficient compared with a commercial lysosomal location dye.

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Publication details

The article was received on 22 Mar 2017, accepted on 19 May 2017 and first published on 19 May 2017


Article type: Letter
DOI: 10.1039/C7NJ00949F
Citation: New J. Chem., 2017, Accepted Manuscript
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    A Fluorescent Probe for Ratiometric Imaging Exogenous and Intracellular Formed Hypochlorous Acid in Lysosomes

    M. Ren, J. Nie, B. Deng, K. Zhou, J. Wang and W. Lin, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00949F

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