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Catalyst-free ultrasonic-promoted multicomponent synthesis of tertiary α-amino phosphonates

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Abstract

A highly efficient and green protocol has been developed for the synthesis of a new class of tertiary α-amino phosphonates (TAPs) via the Kabachnik–Fields reactions of substituted salicylaldehydes and 2-hydroxy naphthaldehyde, di-n-butylamine, and di-or tri-alkylphosphites in water under ultrasound irradiation as well as under conventional conditions. These multi-component reactions were performed at room temperature without using any catalysts in water. The TAPs were obtained in higher yields (84% to 94%) within shorter reaction times (6 min to 35 min) than those of conventional reactions after simple workup and purification procedures.

Graphical abstract: Catalyst-free ultrasonic-promoted multicomponent synthesis of tertiary α-amino phosphonates

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Publication details

The article was received on 22 Mar 2017, accepted on 01 Jun 2017 and first published on 02 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00944E
Citation: New J. Chem., 2017, Advance Article
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    Catalyst-free ultrasonic-promoted multicomponent synthesis of tertiary α-amino phosphonates

    R. M. N. Kalla, J. Bae and I. Kim, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ00944E

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