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Molecularly imprinted polymers on CdS quantum dots for sensitive determination of cefixime after its preconcentration by magnetic graphene oxide

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Abstract

A sensitive and selective method was developed for the simple monitoring of cefixime based on its preconcentration by magnetic Fe3O4@SiO2 modified graphene oxide (Fe3O4@SiO2-GO) and fluorimetric detection using molecularly imprinted polymer coated CdS quantum dots (MIP-CdS QDs). GO was simply synthesized using the Hummers method and then was modified using Fe3O4@SiO2 nanoparticles. MIP-CdS QDs were obtained by copolymerization of certain monomers in the presence of CdS QDs as fluorescent materials and cefixime as a template molecule. The obtained nanomaterials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). MIP-CdS QDs showed a high tendency towards cefixime, and the adsorbed cefixime molecules led to a linear increase in the emission intensity of QDs. Based on this effect, a selective determination method was designed for cefixime. To detect lower cefixime concentrations, a preconcentration step was applied. In this regard, the dispersed Fe3O4@SiO2-GO displayed good efficiency to extract low amounts of cefixime as a model analyte. Important parameters including pH, buffer type and concentration, reagent amounts, ionic buffer, incubation time, eluent, etc. were optimized for both the extraction and detection steps. A calibration graph in the concentration range of 0.001–0.7 μg mL−1 was obtained for cefixime with a detection limit (3 s) of 0.54 ng mL−1. The present method was satisfactorily used for cefixime determination in pharmaceutical and urine samples. The results were shown to possess adequate features compared with previous methods.

Graphical abstract: Molecularly imprinted polymers on CdS quantum dots for sensitive determination of cefixime after its preconcentration by magnetic graphene oxide

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Publication details

The article was received on 13 Mar 2017, accepted on 07 Jun 2017 and first published on 26 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00834A
Citation: New J. Chem., 2017, Advance Article
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    Molecularly imprinted polymers on CdS quantum dots for sensitive determination of cefixime after its preconcentration by magnetic graphene oxide

    H. Eskandari, M. Amirzehni, H. Asadollahzadeh and P. Alizadeh Eslami, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ00834A

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