Jump to main content
Jump to site search


Supercritical fluid extraction of papaverine and noscapine from poppy capsules followed by preconcentration with magnetic nano Fe3O4@Cu@diphenylthiocarbazone particles

Author affiliations

Abstract

A novel magnetite adsorbent modified with copper and diphenylthiocarbazone was synthesized and used as a sorbent for magnetic solid phase extraction (MSPE) of two opium alkaloids: papaverine and noscapine. Supercritical fluid extraction (SFE) was used to extract the analytes from poppy capsules. The extracts were preconcentrated by magnetic solid phase extraction. Separation and determination of both opium alkaloids were performed using high performance liquid chromatography with an ultra-violet detector. The SFE parameters were optimized through a Taguchi orthogonal array experimental design. Under the optimal conditions, broad linear dynamic ranges of 0.3–180 μg L−1 (0.9981 < R2 < 0.9993) and 0.3–4 mg kg−1 (0.9921 < R2 < 0.9971), favorable limits of detection of 1 μg L−1 and 0.1 mg kg−1, and suitable precisions with RSDs% in the range of 4.3–5.5% and 5.8–7.7% were obtained for MSPE and SFE-MSPE, respectively. The capability of the method was tested by analyzing different real samples including urinary samples and poppy capsules.

Graphical abstract: Supercritical fluid extraction of papaverine and noscapine from poppy capsules followed by preconcentration with magnetic nano Fe3O4@Cu@diphenylthiocarbazone particles

Back to tab navigation

Publication details

The article was received on 08 Mar 2017, accepted on 14 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00776K
Citation: New J. Chem., 2017, Advance Article
  •   Request permissions

    Supercritical fluid extraction of papaverine and noscapine from poppy capsules followed by preconcentration with magnetic nano Fe3O4@Cu@diphenylthiocarbazone particles

    M. Tajik, Y. Yamini, T. Baheri, M. Safari and H. Asiabi, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ00776K

Search articles by author

Spotlight

Advertisements