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Thiourea functionalized β-cyclodextrin as green reducing and stabilizing agent for silver nanocomposites with enhanced antimicrobial and antioxidant properties

Abstract

Rapid development of microbial resistance against traditional antibiotics has generated a need for the synthesis of new more potent, less toxic, target specific, cost effective and biodegradable antimicrobial agents. Biopolymer based Ag-nanocomposites are a good alternate for this purpose. With auxiliary privilege to be used as prospective stabilizer and emulsifier, a biopolymer reaffirms the edge over traditionally used chemicals in nano-chemistry. In view of the above context, the present investigation involves microwave assisted simple greener method for the synthesis of β-cyclodextrin silver nanocomposites (Ag-NPs), where sulphur functionalized β-cyclodextrin is itself acting as a green reducing and capping agent for silver ion. The constitution and framework of the synthesized thiomer and nanocomposite were characterized by FTIR, XRD and TEM techniques. These studies indicated the homogeneity of the silver nanocomposites with average size of 4 nm via XRD results. Functionalized nanocomposites with unique properties of –SH group and Ag-NP were screened for broad spectrum antimicrobial and antioxidant activity. The antimicrobial results disclosed excellent antimicrobial performance with maximum inhibition zone of 38 mm and MIC value of 0.9 μg mL−1 against E. coli. The sulphur functionalized β-cyclodextrin and their synthesized nanocomposites also exhibited eminent antioxidant properties even at 100 ppm.

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Supplementary files

Publication details

The article was received on 08 Mar 2017, accepted on 08 Sep 2017 and first published on 08 Sep 2017


Article type: Paper
DOI: 10.1039/C7NJ00759K
Citation: New J. Chem., 2017, Accepted Manuscript
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    Thiourea functionalized β-cyclodextrin as green reducing and stabilizing agent for silver nanocomposites with enhanced antimicrobial and antioxidant properties

    R. Sharma, P. Singh, R. Dharela, G. S. Chauhan and K. Chauhan, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00759K

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