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Issue 13, 2017
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Efficient DNA condensation by ruthenium(II) polypyridyl complexes containing triptycenyl functionalized 1,10-phenanthroline

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Abstract

A series of luminescent ruthenium(II) polypyridyl complexes containing an extended aromatic moiety derived from triptycene and 1,10-phenanthroline were synthesized and their photophysical, theoretical, and biological properties were investigated. These complexes rapidly condense DNA into nano-aggregates at room temperature. The DNA interactions and DNA condensation properties of these complexes were investigated by absorption and emission spectroscopy, electrophoretic mobility assay, and atomic force microscopy. Their DNA cleavage inactivity and low toxicity of the complexes satisfy the requirements of a good non-viral gene delivery vector.

Graphical abstract: Efficient DNA condensation by ruthenium(ii) polypyridyl complexes containing triptycenyl functionalized 1,10-phenanthroline

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Publication details

The article was received on 04 Mar 2017, accepted on 22 May 2017 and first published on 22 May 2017


Article type: Paper
DOI: 10.1039/C7NJ00738H
Citation: New J. Chem., 2017,41, 5513-5520
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    Efficient DNA condensation by ruthenium(II) polypyridyl complexes containing triptycenyl functionalized 1,10-phenanthroline

    S. S. Bhat, V. K. Revankar, R. V. Pinjari, N. S, C. Bogar, K. Bhat and V. A. Kawade, New J. Chem., 2017, 41, 5513
    DOI: 10.1039/C7NJ00738H

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