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Synthesis and Characterization of Nanoscale Zeolitic Imidazolate Frameworks with Ciprofloxacin and Their Applications as Antimicrobial Agents

Abstract

The present study investigated antibiotic drug loading in metal-organic frameworks (MOFs). Porous Zeolitic imidazolate frameworks (ZIFs) were synthesized under concentrated aqueous solution. A straightforward nano-precipitating method was used to prepare ciprofloxacin (CIP) - loaded ZIF-8 (CIP-ZIF-8). ZIF-8 and CIP-ZIF-8 were characterized by FT-IR spectroscopy, X-ray powder diffraction, scanning electron microscopy, thermogravimetric analysis, BET nitrogen adsorption–desorption method, and UV–Vis spectroscopy. The thermal behavior of CIP-ZIF-8 was confirmed by thermal analyses. FT-IR spectroscopy illustrated the presence of functional groups of CIP and ZIF-8 frameworks in CIP-ZIF-8. ZIF-8 showed high loading capacity for the model antibiotic drug CIP with a pH-sensitivity release. The as-synthesized CIP-ZIF-8 possesses high drug loading efficiency (21%), and release in pH 5.0 acetate buffer solutions (97 %) was faster than in pH 7.4 phosphate buffers (83%). The antibacterial activities of ZIF-8 and CIP-ZIF-8 were tested against one gram-positive and gram-negative species. The results exhibited that the synthesized materials had good growth inhibition against microorganisms.

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Publication details

The article was received on 21 Feb 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00606C
Citation: New J. Chem., 2017, Accepted Manuscript
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    Synthesis and Characterization of Nanoscale Zeolitic Imidazolate Frameworks with Ciprofloxacin and Their Applications as Antimicrobial Agents

    H. Nabipour, M. Hossaini sadr and G. Rezanejade Bardajee, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00606C

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