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Issue 13, 2017
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Effect of the synthesis method on the performance of Fe3O4–inositol hexaphosphate as a drug delivery vehicle for combination therapeutics with doxorubicin

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Abstract

Herein, Fe3O4–inositol hexaphosphate (Fe3O4–IP6) was fabricated via layer-by-layer electrostatic self-assembly following a solvothermal synthesis method and via a one-step co-precipitation method. The influence of the synthesis method on the controlled drug release and combination therapeutic behaviour of Fe3O4–IP6 was characterized. The two preparation methods resulted in differences in the compound color, particle size, magnetic properties, and drug loading capacity with an optimum initial drug concentration. The sample prepared via the one-step co-precipitation method exhibited a magnetic saturation of 39.23 emu g−1, higher drug loading efficiency for doxorubicin (DOX), and improved anticancer effects than that prepared via the alternative method. However, Fe3O4–IP6 prepared via both methods showed obvious pH sensitivity in weak acidic regions such as tumour tissue, leading to marked inhibition of the regeneration of tumour cells without adverse effects.

Graphical abstract: Effect of the synthesis method on the performance of Fe3O4–inositol hexaphosphate as a drug delivery vehicle for combination therapeutics with doxorubicin

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Publication details

The article was received on 20 Feb 2017, accepted on 02 May 2017 and first published on 03 May 2017


Article type: Paper
DOI: 10.1039/C7NJ00599G
Citation: New J. Chem., 2017,41, 5305-5312
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    Effect of the synthesis method on the performance of Fe3O4–inositol hexaphosphate as a drug delivery vehicle for combination therapeutics with doxorubicin

    D. Xu, T. Xu, X. Guo, Q. Liu, J. Liu, W. Lv, X. Jing, H. Zhang and J. Wang, New J. Chem., 2017, 41, 5305
    DOI: 10.1039/C7NJ00599G

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