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Organic-to-Aqueous Phase Transfer of Zn-Cu-In-Se/ZnS Quantum Dots with Multifunctional Multidentate Polymer Ligands for Biomedical Optical Imaging

Abstract

As the growing trials of biocompatible quantum dots (QDs) in biomedical applications, exploring surface modification of oil-soluble QDs to increase the solubility in water is facing more challenging. Hence, in this report, we described a new approach to synthesize oil-soluble highly luminescent Zn-Cu-In-Se/ZnS (ZCISe/ZnS) QDs with low cytotoxicity. Their photoluminescence (PL) emission could be tuned from 545 to 850 nm by optimizing a series of parameters, and the typical PL quantum yield (QY) is 40-60%. Then, to transfer these oil-soluble QDs into water, the cRGD (c(Arg-Gly-Asp-DTyr-Lys) peptide) modified multifunctional multidentate polymer ligands (cRGD-PME) were fabricated. The phase transfer is based on a ligand-exchange process mediated by thioglycerol. The obtained results show that the cRGD-PME polymer can afford the formulation of the oil-soluble ZCISe/ZnS QDs in water, while retaining their initial morphology, crystal structure, and PL properties. Finally, in vitro and in vivo optical imaging experiments were further explored, indicating that the prepared aqueous ZCISe/ZnS QDs via cRGD-PME ligands have the potential as a versatile fluorescent probe for evaluating the tumor targeting on cells and small animals. This study is also particularly significant for developing new biocompatible QDs-based probes to take place of previous CdSe or CdTe QDs-based ones.

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Publication details

The article was received on 30 Mar 2017, accepted on 19 May 2017 and first published on 19 May 2017


Article type: Paper
DOI: 10.1039/C7NJ00573C
Citation: New J. Chem., 2017, Accepted Manuscript
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    Organic-to-Aqueous Phase Transfer of Zn-Cu-In-Se/ZnS Quantum Dots with Multifunctional Multidentate Polymer Ligands for Biomedical Optical Imaging

    R. Zhang, T. Deng, J. Wang, G. Wu, S. Li, Y. Gu and D. Deng, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00573C

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