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Synthesis, physicochemical characterization and cytotoxic properties of riboflavin loaded Myrj52–silver nanoparticles

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Abstract

The synthesis and physicochemical characterization of riboflavin (RF) loaded Myrj52–silver nanoparticles (SNPs) were performed and their cytotoxic properties were evaluated. Transmission electron microscopy analysis showed the formation of colloidal spherical SNPs with an average size of ∼12 nm. The structure, stability, dynamics and conformation of human serum albumin (HSA) binding RF on SNPs have been studied. The influence of RF on the secondary structure of HSA in the presence of SNPs showed a predominant α-helix structure (61.7%). No changes induced by RF binding to HSA were observed. The cytotoxicity of RF and RF–HSA loaded Myrj52–SNPs was evaluated in vitro using the Neutral Red assay and cell morphology observations in a culture of L929 fibroblast cells. The results have relevance with regard to the RF loaded Myrj52–SNP formulation for pharmaceuticals.

Graphical abstract: Synthesis, physicochemical characterization and cytotoxic properties of riboflavin loaded Myrj52–silver nanoparticles

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Publication details

The article was received on 17 Feb 2017, accepted on 17 May 2017 and first published on 02 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00571G
Citation: New J. Chem., 2017, Advance Article
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    Synthesis, physicochemical characterization and cytotoxic properties of riboflavin loaded Myrj52–silver nanoparticles

    M. Voicescu, S. Ionescu, O. Craciunescu, R. Tatia, L. Moldovan, V. S. Teodorescu and C. L. Nistor, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ00571G

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