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Issue 8, 2017
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De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt(II) aqua nitrate complex

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Abstract

A new potent intercalating entity, mono nitratobis(1,10-phenanthroline)cobalt(II) aqua nitrate, was synthesized and crystallized in the monoclinic P21/n space group, containing hydrogen bond acceptor (O atoms) groups, which mediates the hydrolytic cleavage of plasmid pBR322 DNA. The kinetic aspects of DNA cleavage analyzed by the T4 DNA ligase assay are detailed.

Graphical abstract: De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt(ii) aqua nitrate complex

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Publication details

The article was received on 16 Feb 2017, accepted on 01 Mar 2017 and first published on 02 Mar 2017


Article type: Letter
DOI: 10.1039/C7NJ00563F
Citation: New J. Chem., 2017,41, 2883-2886
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    De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt(II) aqua nitrate complex

    S. Sharma, L. Toupet and F. Arjmand, New J. Chem., 2017, 41, 2883
    DOI: 10.1039/C7NJ00563F

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