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Synthesis, magnetic and cytotoxic properties of copper(II) halide complexes with 1,2,4-triazolo[1,5-a] benzimidazoles

Abstract

Coordination compounds based on copper(II) halides with 4H-1,2,4-triazolo[1,5-a]benzimidazole (L1), 3-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L2), 4-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L3) with the compositions [Cu(L1)2(Hal)2]·nH2O (Hal = Cl, n = 0.5 (I) Br, n = 1 (II)); [Cu(L2)2Cl2] (III), [Cu(L3)2Cl2] (IV) and [Cu(L3)2Br2(H2O)]·2H2O (V) were synthesized. The compounds were characterized using X-ray diffraction, UV-Vis spectroscopy (diffuse reflectance spectra), infrared spectroscopy, and static magnetic susceptibility measurements. By means of X-ray diffraction structural analysis, crystal structures were determined for the [Cu(L3)2(Hal)2(H2O)]∙2H2O complexes, where Hal = Cl (IVa), and Br (V). Cytotoxic effects of the complexes and ligands on cell line Hep-2 was then studied, and we found that the copper(II) complex with ligands L1-L3 leads to a considerable enhancement of cytotoxicity.

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Publication details

The article was received on 14 Feb 2017, accepted on 21 Apr 2017 and first published on 21 Apr 2017


Article type: Paper
DOI: 10.1039/C7NJ00533D
Citation: New J. Chem., 2017, Accepted Manuscript
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    Synthesis, magnetic and cytotoxic properties of copper(II) halide complexes with 1,2,4-triazolo[1,5-a] benzimidazoles

    L. G. Lavrenova, T. A. Kuz'menko, A. D. Ivanova, A. I. Smolentsev, V. Komarov, A. S. Bogomyakov, L. A. Sheludyakova and E. V. Vorontsova, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00533D

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