Synthesis, magnetic and cytotoxic properties of copper(II) halide complexes with 1,2,4-triazolo[1,5-a] benzimidazoles
Coordination compounds based on copper(II) halides with 4H-1,2,4-triazolo[1,5-a]benzimidazole (L1), 3-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L2), 4-methyl-1,2,4-triazolo[1,5-a]benzimidazole (L3) with the compositions [Cu(L1)2(Hal)2]·nH2O (Hal = Cl–, n = 0.5 (I) Br–, n = 1 (II)); [Cu(L2)2Cl2] (III), [Cu(L3)2Cl2] (IV) and [Cu(L3)2Br2(H2O)]·2H2O (V) were synthesized. The compounds were characterized using X-ray diffraction, UV-Vis spectroscopy (diffuse reflectance spectra), infrared spectroscopy, and static magnetic susceptibility measurements. By means of X-ray diffraction structural analysis, crystal structures were determined for the [Cu(L3)2(Hal)2(H2O)]∙2H2O complexes, where Hal = Cl– (IVa), and Br– (V). Cytotoxic effects of the complexes and ligands on cell line Hep-2 was then studied, and we found that the copper(II) complex with ligands L1-L3 leads to a considerable enhancement of cytotoxicity.