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Delivery and releasing of microRNA-34a into MCF-7 breast cancer cell by using spherical nucleic acid nanocarriers

Abstract

Herein, we designed and prepared two sets of spherical nucleic acid (SNA) nanocarriers to deliver and release microRNA-34a (miR-34a) in MCF-7 breast cancer cell. In this strategy, survivin mRNA is used as a trigger to start the running of the SNA-based delivery system, resulting in the release of miR-34a from SNA nanocarriers. The quantitative RT-PCR shows a significant decrease in mRNA level and ectopic expression of miR-34a. Meanwhile, the released miR-34a mimics largely reduce the cell viability and induce apoptosis, suggesting the high-efficiency and availability of this SNA-based delivery system.

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Publication details

The article was received on 13 Feb 2017, accepted on 08 May 2017 and first published on 09 May 2017


Article type: Letter
DOI: 10.1039/C7NJ00510E
Citation: New J. Chem., 2017, Accepted Manuscript
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    Delivery and releasing of microRNA-34a into MCF-7 breast cancer cell by using spherical nucleic acid nanocarriers

    H. Li, W. Shen, M. H. W. Lam and H. Liang, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00510E

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