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PEG-600 mediated one-pot reaction of 3-acetyl-2H-chromen-2-one with heterylthiols and phenylthioureas using Tetrabutylammonium Tribromide as an efficient green reagent

Abstract

A facile method for the one-pot reaction of 3-acetyl-2H-chromen-2-one with different heterylthiols and phenylthioureas has been described under green conditions using tetrabutylammonium tribromide (TBATB) as an efficient reagent. 3-acetyl-2H-chromen-2-one reacted with TBATB in acetic acid to give 3-(2-bromoacetyl)-2H-chromen-2-one. The effect of solvent on this reaction has been studied. PEG-600 was found to be the effective solvent for this reaction. Thus, one-pot reaction of equimolar amounts of 3-acetyl-2H-chromen-2-one, TBATB & heterylthiols/phenylthioureas independently, resulted in the formation of heterylthioacetylcoumarins and coumarinylthiazoles respectively. Effect of solvent on these reactions has been studied. The merits of this preparation are mild reaction conditions, easy workup, good yields and use of PEG-600 as green reaction media.

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Publication details

The article was received on 12 Feb 2017, accepted on 09 May 2017 and first published on 09 May 2017


Article type: Paper
DOI: 10.1039/C7NJ00504K
Citation: New J. Chem., 2017, Accepted Manuscript
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    PEG-600 mediated one-pot reaction of 3-acetyl-2H-chromen-2-one with heterylthiols and phenylthioureas using Tetrabutylammonium Tribromide as an efficient green reagent

    S. Devulapally and D. P.K, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00504K

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