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Issue 10, 2017
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Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activity

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Abstract

Phenazinic ligands and Ru(II)-based complexes were synthesized from natural products lapachol and lawsone and evaluated against T. cruzi, the etiological agent of Chagas disease. These new ruthenium compounds could provide promising trypanocidal drugs. Besides synthesis and trypanocidal activity, this paper reports photophysical features and computational details of the compounds. The fluorescent trypanocidal substances are promising derivatives for further studies aiming to find molecules active against parasites associated with neglected diseases.

Graphical abstract: Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activity

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Publication details

The article was received on 01 Feb 2017, accepted on 16 Mar 2017 and first published on 17 Mar 2017


Article type: Paper
DOI: 10.1039/C7NJ00379J
Citation: New J. Chem., 2017,41, 3723-3731
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    Cyclometalated ruthenium complexes from naturally occurring quinones: studies on their photophysical features, computational details and trypanocidal activity

    C. M. de Souza, R. C. Silva, P. O. Fernandes, J. D. de Souza Filho, H. A. Duarte, M. H. Araujo, C. A. de Simone, S. L. de Castro, R. F. S. Menna-Barreto, C. P. Demicheli and E. N. da Silva Júnior, New J. Chem., 2017, 41, 3723
    DOI: 10.1039/C7NJ00379J

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