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Design and in vitro biological evaluation of substituted chalcones synthesized from Nitrogen mustards as potent microtubule targeted anticancer agents

Abstract

A new series of p-[N, N-bis(2-chloroethyl)amino]benzaldehyde substituted chalcone derivatives were designed, synthesized and their structures characterized by spectroscopic techniques and single crystal XRD studies. Compounds 3a-f were crystallized in the triclinic system with centrosymmetric space group P-1 except crystal 3c which was in the monoclinic crystal system with centrosymmetric space group P21/c. Molecular docking studies were utilized to reveal the binding mode of the derivatives to identify new tubulin inhibitors. Density functional theory calculations were performed to understand the structural and electronic properties of these chalcones. The DFT results show that the HOMO of all chalcones lies in the range -5.65 to -6.17 eV and LUMO in the range -2.01 to -3.21 eV. The experimental results are well supported by the theoretical structural analysis. The biological activity of these compounds showed high potency of growth inhibitory effects with sub-micromolar IC50 values ranging from 0.089 to 0.200 µM against A549 and HepG2 cancer cell lines. Further, these compounds exhibited a strong inhibitory effect on tubulin polymerization. 3e showed the highest mean activity against both the cancer cells and in tubulin inhibition. This correlated well with the theoretical results from the pharmacophore binding model. Hence, these six compounds particularly 3e, could be considered as potential leads in the development of new anticancer agents.

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Publication details

The article was received on 21 Jan 2017, accepted on 18 Apr 2017 and first published on 18 Apr 2017


Article type: Paper
DOI: 10.1039/C7NJ00265C
Citation: New J. Chem., 2017, Accepted Manuscript
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    Design and in vitro biological evaluation of substituted chalcones synthesized from Nitrogen mustards as potent microtubule targeted anticancer agents

    J. S. Xavier, J. Karthikeyan, G. Velmurugan, M. T. Manoharan and A. N. Shetty, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00265C

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