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Issue 14, 2017
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Highly fluorescent nitrogen-doped graphene quantum dots as a green, economical and facile sensor for the determination of sunitinib in real samples

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Abstract

The preparation of nitrogen-doped graphene quantum dots (N-GQDs), by a simple and inexpensive synthetic procedure, is reported with blue emission and a high quantum yield of 78%. This procedure involves synthesis via the pyrolysis of citric acid, as a source of carbon, and tris-hydroxymethyl aminomethane, as a surface passivation agent. These N-GQDs have low toxicity and are photostable. They displayed excitation-independent behavior, although their fluorescence intensity was linearly dependent on pH values ranging from 3 to 10. The quenching of the fluorescence intensity of the N-GQDs increases, in a relatively very small amount of time, with the addition of sunitinib varying from 0.05 to 20.00 μmol L−1 and with a detection limit of 0.03 μmol L−1. The N-GQDs have low toxicity and are pH-sensitive between 3.00 and 10.00, giving a general pH-sensor with a wide range of applications in real urine and serum samples.

Graphical abstract: Highly fluorescent nitrogen-doped graphene quantum dots as a green, economical and facile sensor for the determination of sunitinib in real samples

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Publication details

The article was received on 21 Jan 2017, accepted on 09 Jun 2017 and first published on 09 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00262A
Citation: New J. Chem., 2017,41, 6875-6882
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    Highly fluorescent nitrogen-doped graphene quantum dots as a green, economical and facile sensor for the determination of sunitinib in real samples

    H. M. Kashani, T. Madrakian and A. Afkhami, New J. Chem., 2017, 41, 6875
    DOI: 10.1039/C7NJ00262A

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