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Tunable Near-Infrared Fluorescent Gold Nanoclusters: Temperature Sensor and Targeted Bioimaging

Abstract

Near-infrared (NIR) fluorescence nanomaterials with low toxicity and long wavelength emission play an important role in bioapplications. Herein, a simple and rapid microwave heating method is designed to synthesize fluorescent gold nanoclusters (AuNCs) by using glutathione (GSH) as reducing agent and stabilizing agent simultaneously. By adjusting microwave heating time, as-prepared GSH−AuNCs can show size-dependent tunable fluorescence from visible region to NIR region, even to 800 nm wavelength. Besides, as-prepared GSH−AuNCs are water-soluble, low toxic, high stable and multifunctional surface chemistry based on GSH as the protective surface layer. Another attractive nature of resultant NIR GSH−AuNCs is temperature-dependent fluorescence and could be used as nanoprobe to measure temperature range from 0 to 80 °C. Moreover, this process is reversible, which means the fluorescence intensity of GSH−AuNCs can be recovered to the initial intensity when the temperature changes reversibly. Finally, resultant NIR GSH−AuNCs are further conjugated with folic acids (FA) which helps AuNCs target HeLa cells. These properties provide FA-conjugated GSH−AuNCs with potential applications as a platform for cancer diagnosis studies in various biological systems.

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Publication details

The article was received on 15 Jan 2017, accepted on 18 May 2017 and first published on 19 May 2017


Article type: Paper
DOI: 10.1039/C7NJ00175D
Citation: New J. Chem., 2017, Accepted Manuscript
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    Tunable Near-Infrared Fluorescent Gold Nanoclusters: Temperature Sensor and Targeted Bioimaging

    Y. Sun, J. Wu, C. Wang, Y. Zhao and Q. Lin, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00175D

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