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A facile method to fabricate hydrogels from DMSO polymer gels via solvent exchange


A mixture of the bipyridine, phenyl and/or cyclohexanediamine-based building blocks 1, 2, and/or 3, having hydrazide, aldehyde or amine moieties, respectively, formed DMSO polymer gels by the hydrazone reaction in the acidic conditions. These DMSO gels were transformed into the hydrogels without shape change by solvent exchange. Interestingly, G’ and G” values of the hydrogels increased 9~12-fold due to formation of a three-dimensional network structure by intermolecular hydrogen bonding interactions. In sweep measurements, γ values of the hydrogels prepared without NaCl were enhanced from 18.5% to 46~55%, which was attributed to the three-dimensional network with additional intermolecular hydrogen-bonding interactions. Furthermore, a gel-to-quasi-liquid transition was completely reversible, where G’ and G” values were recovered rapidly within 60s. This reversibility was a thixotropic response. In addition, no significant cytotoxicity of hydrogels was observed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo¬lium bromide) assay, indicating that the hydrogels could be used in various biological applications.

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Publication details

The article was received on 13 Jan 2017, accepted on 17 May 2017 and first published on 18 May 2017

Article type: Letter
DOI: 10.1039/C7NJ00152E
Citation: New J. Chem., 2017, Accepted Manuscript
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    A facile method to fabricate hydrogels from DMSO polymer gels via solvent exchange

    H. Choi, M. Go, Y. Cha, Y. Choi, K. Kwon and J. H. Jung, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00152E

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