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Boronate-affinity hollow molecularly imprinted polymers for the selective extraction of nucleosides

Abstract

Boronate-affinity hollow molecularly imprinted polymers (h-MIPs) were prepared and applied to selective enrichment of four nucleosides in traditional Chinese medicine injection samples, followed by HPLC detection. The synthesis mechanism of the h-MIPs was studied. Due to a large amount of boronic acid groups introduced by 3-aminophenylboronic acid (APBA) on the outermost polymer shell of the MIPs, which was of great importance to improve the enrichment efficiency for nucleosides. Furthermore, owing to the hollow structure of the h-MIPs, more binding cavities were located on the inner and outer surfaces of the h-MIPs, which could facilitate the removal of template molecules from the polymers and the rebinding of the target molecules to the polymers. Under the optimal conditions, the detection limits of four nucleosides are in the range of 0.0120.033 μg mL−1. At the different spiked levels, the recoveries of nucleosides are in the range of 63.8%108.9%. The proposed method was successfully applied to determine four nucleosides in five injection samples. The boronate-affinity h-MIPs provided a promising selective enrichment platform for precise nucleosides analysis.

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Publication details

The article was received on 13 Jan 2017, accepted on 01 Jun 2017 and first published on 02 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ00148G
Citation: New J. Chem., 2017, Accepted Manuscript
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    Boronate-affinity hollow molecularly imprinted polymers for the selective extraction of nucleosides

    Y. Hu, W. Huang, Y. Tong, Q. Xia and M. Tian, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00148G

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