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Issue 15, 2017
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Stimuli-responsive α-helical peptide gatekeepers for mesoporous silica nanocarriers

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Abstract

Among the numerous gatekeepers, peptides have attracted much interest due to their specific targeting, cell penetrating, endo-/lysosomal escaping, and enzymatic degrading capabilities. Recently, we developed peptide gatekeepers with turn structures that were triggered to release via stimuli-responsive conformational conversion. In this report, to extend the utilization of stimuli-responsive peptide gatekeepers on the surface of MSNs, we prepared α-helical peptide gatekeepers with a capability for stimuli-responsive conformational conversion on the surface of mesoporous silica nanoparticles. The stimuli-responsive α-helical peptide gatekeepers controlled the release of entrapped drugs triggered by GSH addition and consequential conformational conversion. Furthermore, the nanoparticles efficiently disrupted the liposome membranes. Therefore, stimuli-responsive α-helical peptide gatekeepers would be useful for the construction of mesoporous delivery vehicles with enhanced therapeutic efficacy via membrane disruption.

Graphical abstract: Stimuli-responsive α-helical peptide gatekeepers for mesoporous silica nanocarriers

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Publication details

The article was received on 10 Jan 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Letter
DOI: 10.1039/C7NJ00124J
Citation: New J. Chem., 2017,41, 6969-6972
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    Stimuli-responsive α-helical peptide gatekeepers for mesoporous silica nanocarriers

    J. Lee, S. Han, J. Lee, M. Choi and C. Kim, New J. Chem., 2017, 41, 6969
    DOI: 10.1039/C7NJ00124J

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