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Stimuli-Responsive α-Helical Peptide Gatekeepers for Mesoporous Silica Nanocarriers

Abstract

Among numerous gatekeepers, peptides have been attracted much interests due to their specific targeting, cell penetrating, endo-/lysosomal escaping, or enzymatic degrading capabilities. Recently, we developed peptide gatekeepers with turn structure being triggered to release by stimuli-responsive conformational conversion. In this report, to extend the utilization of the stimuli-responsive peptide gatekeepers on the surface of MSNs, we prepared α-helical peptide gatekeepers with a capability of stimuli-responsive conformational conversion on the surface of mesoporous silica nanoparticles. The stimuli-responsive α-helical peptide gatekeepers controlled the release of entrapped drugs triggered by GSH addition and consequential conformational conversion. Furthermore, the nanoparticles efficiently disrupted the liposome membrane. Therefore, stimuli-responsive α-helical peptide gatekeepers would be useful for construction of mesoporous delivery vehicle with enhanced therapeutic efficacy via membrane disruption.

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Publication details

The article was received on 10 Jan 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Letter
DOI: 10.1039/C7NJ00124J
Citation: New J. Chem., 2017, Accepted Manuscript
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    Stimuli-Responsive α-Helical Peptide Gatekeepers for Mesoporous Silica Nanocarriers

    J. Lee, S. Han, J. Lee, M. Choi and C. Kim, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ00124J

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