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Issue 14, 2017
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Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents

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Abstract

In this work, we present the physicochemical characterization and structural determination of two sulfonylhydrazone derivatives: LASSBio-1773 and LASSBio-1774. The former compound has displayed hypoglycemic activity and has reduced the thermal hyperalgesia and mechanical allodynia in a murine model of diabetic neuropathic pain induced by streptozotocin. In order to stablish the differences in the three-dimensional characteristics of these original bioactive compounds, we determined their crystal structures – by using X-ray powder diffraction data and a simulated annealing procedure – and studied their thermal stability. Furthermore, we performed crystal morphology prediction and compared it with SEM photomicrographs: the evidenced good agreement allowed us to suggest alternative crystallization routes – to overcome the low-solubility of LASSBio-1773 and LASSBio-1774 – as evidenced by IDR tests.

Graphical abstract: Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents

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Publication details

The article was received on 06 Jan 2017, accepted on 27 May 2017 and first published on 29 May 2017


Article type: Paper
DOI: 10.1039/C7NJ00074J
Citation: New J. Chem., 2017,41, 6464-6474
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    Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents

    A. L. Ibiapino, L. P. de Figueiredo, L. M. Lima, E. J. Barreiro, F. Punzo and F. F. Ferreira, New J. Chem., 2017, 41, 6464
    DOI: 10.1039/C7NJ00074J

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