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Issue 11, 2017
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Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

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Abstract

An unusual alkaloid, talaramide A (1), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1). The structure of 1 was established by analysis of NMR spectroscopic data, X-ray diffraction data, and electronic circular dichroism (ECD) spectra. Talaramide A (1) is the second example of an alkaloid that possesses a unique oxidized tricyclic system. A possible biosynthetic pathway for 1 was proposed. Compound 1 showed promising inhibition of mycobacterial PknG activity with an IC50 value of 55 μM.

Graphical abstract: Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

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Publication details

The article was received on 05 Jan 2017, accepted on 11 Apr 2017 and first published on 12 Apr 2017


Article type: Letter
DOI: 10.1039/C7NJ00059F
Citation: New J. Chem., 2017,41, 4273-4276
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    Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

    S. Chen, L. He, D. Chen, R. Cai, Y. Long, Y. Lu and Z. She, New J. Chem., 2017, 41, 4273
    DOI: 10.1039/C7NJ00059F

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