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Issue 10, 2017
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Sulfamic acid catalyzed one-pot, three-component green approach: synthesis and cytotoxic evaluation of pyrazolyl-thiazole congeners

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Abstract

An efficient, operationally simple and one-pot multi-component approach has been developed for the construction of pyrazolyl-thiazoles using sulfamic acid (H2NSO3H) as a green catalyst in water. The notable features of this protocol include mild reaction conditions, enhanced selectivity with good yields and wide substrate scope, which makes it an attractive and useful process for the synthesis of biologically important newer pyrazolyl-thiazole compounds. A series of compounds (4a–z) were synthesized and also evaluated for their cytotoxic activity against three human cancer cell lines. Among them, 4b, 4c and 4e exhibited considerable cytotoxicity with an IC50 value of < 5 μM.

Graphical abstract: Sulfamic acid catalyzed one-pot, three-component green approach: synthesis and cytotoxic evaluation of pyrazolyl-thiazole congeners

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Publication details

The article was received on 04 Jan 2017, accepted on 16 Mar 2017 and first published on 17 Mar 2017


Article type: Paper
DOI: 10.1039/C7NJ00042A
Citation: New J. Chem., 2017,41, 3745-3749
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    Sulfamic acid catalyzed one-pot, three-component green approach: synthesis and cytotoxic evaluation of pyrazolyl-thiazole congeners

    B. Sridevi, Y. Tangella, K. S. Babu, J. B. Nanubolu, R. Sunitha Rani, C. Ganesh Kumar, H. M. Meshram and A. Kamal, New J. Chem., 2017, 41, 3745
    DOI: 10.1039/C7NJ00042A

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