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Issue 13, 2017
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Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

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Abstract

Choline hydroxide has been found to be an efficient basic ionic liquid catalyst for the synthesis of α-hydroxyphosphonates. Hydrophosphonylation of aldehydes was performed via the nucleophilic addition of diethylphosphite to aldehydic carbonyl compounds, in the presence of choline hydroxide under neat as well as solvent conditions. A wide array of substrates, including aromatic, fused aromatic, and heterocyclic aldehydes, were efficiently converted to their corresponding products in good yields. This protocol provides an alternative method for the straightforward synthesis of α-hydroxyphosphonates in high yields.

Graphical abstract: Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

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Publication details

The article was received on 16 Dec 2016, accepted on 12 May 2017 and first published on 15 May 2017


Article type: Paper
DOI: 10.1039/C6NJ03948K
Citation: New J. Chem., 2017,41, 5373-5379
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    Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

    R. M. N. Kalla, Y. Zhang and I. Kim, New J. Chem., 2017, 41, 5373
    DOI: 10.1039/C6NJ03948K

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