An efficient synthesis of nitrile, tetrazole and urea from carbonyl compounds

Abstract

An efficient conversion of carbonyl compounds (aldehydes and ketones) to nitrile, tetrazole, and urea was developed with the use of a POCl₃ and sodium azide mixture using a convergent and microwave method. This is the first report on the direct conversion of ketone to urea. The synthesized compounds were characterized by ¹H NMR, ¹³C NMR, mass and IR spectroscopies and were found to be in agreement with reported compounds.