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Issue 7, 2017
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An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

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Abstract

An efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-difluoroalkyl derivatives via a one-pot cascade reaction has been developed. The reaction proceeded smoothly in the presence of In(OTf)3 and afforded a broad scope of isoindolinones with moderate to good yields. Moreover, the reaction could be run on a gram-scale with comparable yield.

Graphical abstract: An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

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Publication details

The article was received on 06 Dec 2016, accepted on 01 Mar 2017 and first published on 02 Mar 2017


Article type: Letter
DOI: 10.1039/C6NJ03813A
Citation: New J. Chem., 2017,41, 2519-2522
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    An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

    T. Chen and C. Cai, New J. Chem., 2017, 41, 2519
    DOI: 10.1039/C6NJ03813A

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