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Issue 8, 2017
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Biologically inspired self-assembly of bacitracin-based platinum nanoparticles with anti-tumor effects

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Abstract

In recent years, there has been increasing interest in fabricating noble metal nanoparticles using bio-templates for various biomedical applications, with the hope of finding a low cost method for their construction by a fairly simple and environmentally friendly synthetic strategy. In this study, novel self-assembled superstructures, namely, bacitracinplatinum nanoparticles (Bac–PtNPs), were designed and prepared under mild conditions. Bacitracin has two purposes: self-assembly to form a specific structure and the recognition of platinum nanoparticles, providing nucleation sites to form the nanomaterials. The spherical chain-like Bac–PtNPs were synthesized by the incubation of bacitracin and PtCl4 aqueous solutions at pH 2.0 for 24 h. The nanoparticles were face-centered cubic (fcc) crystalline, which were stable in aqueous solution. Functional groups such as –NH and –OH on the bacitracin surface serve as binding moieties and mediated the initial growth of the Pt nanoparticles. Anti-tumor effects exhibiting excellent therapeutic efficacy were confirmed both in vitro and in vivo. This study introduces a simple and effective platform for the design and preparation of the antitumor nanocomplexes, highlighting their potential applications in the biomedical field.

Graphical abstract: Biologically inspired self-assembly of bacitracin-based platinum nanoparticles with anti-tumor effects

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Publication details

The article was received on 22 Oct 2016, accepted on 22 Feb 2017 and first published on 23 Feb 2017


Article type: Paper
DOI: 10.1039/C6NJ03302D
Citation: New J. Chem., 2017,41, 2941-2948
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    Biologically inspired self-assembly of bacitracin-based platinum nanoparticles with anti-tumor effects

    T. Yin, Z. Wang, X. Li, Y. Li, K. Bian, W. Cao, Y. He, H. Liu, K. Niu and D. Gao, New J. Chem., 2017, 41, 2941
    DOI: 10.1039/C6NJ03302D

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