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A New Possible Way of Anthracycline Cytostatics Decontamination

Abstract

The widespread use of cytotoxic drugs in the treatment of cancer has led to production of large amounts of contaminated wastes with high exposure risk of medical staff handling cytostatics. For this reason is essential to use for decontamination process highly effective and fast decontamination agent. Currently used decontamination agents based on NaOCl and NaOH according our results and also literature data are not sufficient enough. Therefore we develop a new decontamination agent based an titania nanoparticules, which seems to be very a efficient and fast decotamination agent according our research data. Anthracycline antibiotics are valuable and frequently used drugs in various chemotherapeutic schemes. They have high efficacy, but also high toxicity, e.g. myelosuppression and cardiotoxicity. They can also act as vesicants in the case of extravasation. Due to their mechanism of action, they have a mutagenic and cancerogenic effects. Long term contact, even with the trace amount, can cause changes in the human health. Safe decontamination of cytotoxic drug contaminated area with an agent, which can cause degradation to non-toxic products, is essential. High sorption ability of doxorubicin and epirubicin to titania predisposes TiO2 become a new, effective and inexpensive agent for area decontamination and degradation of anthracycline antibiotics.

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Publication details

The article was received on 27 Dec 2016, accepted on 09 Apr 2017 and first published on 10 Apr 2017


Article type: Paper
DOI: 10.1039/C6NJ03051C
Citation: New J. Chem., 2017, Accepted Manuscript
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    A New Possible Way of Anthracycline Cytostatics Decontamination

    V. Stengl, M. Slusna, J. Tolasz, M. Stastny, S. Popelka and I. R. Stenglova Netikova, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C6NJ03051C

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