Jump to main content
Jump to site search


Computational approaches on cell-nanomaterials interaction: keeping balance between therapeutic efficiency and cytotoxicity

Abstract

Owing to their unique properties, nanomaterials have been widely used in biomedicine since they have obvious inherent advantages over traditional ones. However, nanomaterials may also cause dysfunction in proteins, genes and cells, resulting in cytotoxic and genotoxic responses. Recently, more and more attentions have been paid to these potential toxicities of nanomaterials, especially for the risks of nanomaterials to human health and safety. Therefore, when using nanomaterials for biomedical application, it is of great importance to keep the balance between therapeutic efficiency and cytotoxicity ({i.e., increase the therapeutic efficiency as well as decrease the potential toxicity). This requires a deeper understanding of the interactions between various types of nanomaterials and biological system at nano/bio interface. In this review, from the point of view of theoretical researchers, we will present the current status on physical mechanism of cytotoxicity caused by nanomaterials, mainly based on recent simulation results. Besides, the strategy for minimizing the nanotoxicity naturally and artificially will also be discussed in details, respectively. Further, we should notice that the toxicity is not always bad for clinical use since causing the death of specific cells is the main way of disease treatment. Enhancing the targeting ability of nanomaterials to diseased cells and minimizing their side effect on normal cells should always be hugely challenging issues in nanomedicine. Combining the latest computational works with some experimental verifications, we will provide special insights into recent advances on these problems, especially for the design of novel environment-responsive nanomaterials.

Back to tab navigation

Publication details

The article was received on 02 Sep 2017, accepted on 03 Oct 2017 and first published on 03 Oct 2017


Article type: Review Article
DOI: 10.1039/C7NH00138J
Citation: Nanoscale Horiz., 2017, Accepted Manuscript
  •   Request permissions

    Computational approaches on cell-nanomaterials interaction: keeping balance between therapeutic efficiency and cytotoxicity

    H. Ding and Y. Ma, Nanoscale Horiz., 2017, Accepted Manuscript , DOI: 10.1039/C7NH00138J

Search articles by author

Spotlight

Advertisements