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CHRONIC INTOXICATION BY METHYLMERCURY LEAD TO OXIDATIVE DAMAGE AND CELL DEATH IN SALIVARY GLANDS OF RATS

Abstract

Methylmercury (MeHg) is one of the most toxic species of mercury, causing several systemic damages, but little is known about its effect in the salivary glands. This study aimed to analyze the mercury deposit, oxidative stress markers and cell viability in parotid and submandibular rat salivary glands, after chronic methylmercury intoxication. Forty male Wistar rats (40 days old) were used on the experiment. The animals of the experimental group were intoxicated by intragastric gavage with MeHg at a dose of 0.04 mg/kg/day for 35 days, while the control group received only vehicle. After the period of intoxication, the glands were collected for evaluation of total mercury deposit, cell viability and the malondialdehyde (MDA) and the nitrites levels. Our results showed mercury deposits in salivary glands, with a decrease on cell viability, a higher levels of MDA in both glands of intoxicated animals and a higher concentration of nitrite only in the submandibular gland of mercury group. Thus, the intoxication by MeHg was able to generate deposits and oxidative stress in salivary glands, culminating in a decrease of cell viability in both types of glands.

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Publication details

The article was received on 26 May 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7MT00168A
Citation: Metallomics, 2017, Accepted Manuscript
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    CHRONIC INTOXICATION BY METHYLMERCURY LEAD TO OXIDATIVE DAMAGE AND CELL DEATH IN SALIVARY GLANDS OF RATS

    P. M. Farias-Junior, F. B. Teixeira, N. C. F. Fagundes, R. S. O. Paraense, G. H. N. Miranda, L. O. Bittencourt, M. C. F. Silva, F. Sagica, E. H. C. Oliviera, M. E. Crespo-López and R. R. Lima, Metallomics, 2017, Accepted Manuscript , DOI: 10.1039/C7MT00168A

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