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Recent structural insights into the function of copper nitrite reductases

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Abstract

Copper nitrite reductases (CuNiR) carry out the first committed step of the denitrification pathway of the global nitrogen cycle, the reduction of nitrite (NO2) to nitric oxide (NO). As such, they are of major agronomic and environmental importance. CuNiRs occur primarily in denitrifying soil bacteria which carry out the overall reduction of nitrate to dinitrogen. In this article, we review the insights gained into copper nitrite reductase (CuNiR) function from three dimensional structures. We particularly focus on developments over the last decade, including insights from serial femtosecond crystallography using X-ray free electron lasers (XFELs) and from the recently discovered 3-domain CuNiRs.

Graphical abstract: Recent structural insights into the function of copper nitrite reductases

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Publication details

The article was received on 05 May 2017, accepted on 27 Jun 2017 and first published on 28 Jun 2017


Article type: Critical Review
DOI: 10.1039/C7MT00146K
Citation: Metallomics, 2017, Advance Article
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    Recent structural insights into the function of copper nitrite reductases

    S. Horrell, D. Kekilli, R. W. Strange and M. A. Hough, Metallomics, 2017, Advance Article , DOI: 10.1039/C7MT00146K

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