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The transferrin receptor: the cellular iron gate

Abstract

The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels. In this review, we discussed the latest advances about the molecular regulation of TfR1 expression and we considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells

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Publication details

The article was received on 02 May 2017, accepted on 13 Jun 2017 and first published on 13 Jun 2017


Article type: Critical Review
DOI: 10.1039/C7MT00143F
Citation: Metallomics, 2017, Accepted Manuscript
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    The transferrin receptor: the cellular iron gate

    E. Gammella, P. Buratti, G. Cairo and S. Recalcati, Metallomics, 2017, Accepted Manuscript , DOI: 10.1039/C7MT00143F

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