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Issue 10, 2017
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The transferrin receptor: the cellular iron gate

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The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels. In this review, we have discussed the latest advances in the molecular regulation of TfR1 expression and we have considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells.

Graphical abstract: The transferrin receptor: the cellular iron gate

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The article was received on 02 May 2017, accepted on 13 Jun 2017 and first published on 13 Jun 2017

Article type: Critical Review
DOI: 10.1039/C7MT00143F
Citation: Metallomics, 2017,9, 1367-1375
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    The transferrin receptor: the cellular iron gate

    E. Gammella, P. Buratti, G. Cairo and S. Recalcati, Metallomics, 2017, 9, 1367
    DOI: 10.1039/C7MT00143F

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